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St Leo the Great was probably born in Rome. He became pope in 440. Pope Leo defended the Church against the heresies of Pelagianism and Manichaeism. His Tome on the two natures of Christ (Human and Divine) was adopted by the Council of Chalcedon. He was given the title "the Great" after defending Rome from the marauding Huns and Vandals under Attila. St Leo died in 461.

Benedict XVI speaks about Leo the Great (General Audience)